QnrS1 structure-activity relationships

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QnrS1 structure-activity relationships.

OBJECTIVES Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed. METHODS qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were expressed in Escherichia coli BL21(DE3) and proteins were purified by affinity chromatography. Ciproflox...

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Research works proposed that radical scavenging activity of flavonoids is due to ring B, andthe remaining part of the molecule can be disregarded. Thus the objective of this work is toobserve whether hydroxytoluenes account the radical scavenging activity of flavonoid and toestablish structural requirements for their activity (as they showed appreciable activity) andelucidate a comprehensive me...

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Structure-activity relationships of saframycins.

In vitro antitumor activities of 13 saframycins, including the potent antitumor component, saframycin A, were determined with the highly sensitive established cell line of L1210 mouse leukemia to investigate structure-activity relationships. Saframycins which lack the alpha-cyanoamine group or the alpha-carbinolamine group exhibited much lower cytotoxic activity than saframycin A. The modificat...

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Human follitropin: Structure-activity relationships

Studies of human follitropin (hFSH) structure-activity relationships from the author' s laboratory are reviewed. These include mutagenesis studies that complemented the determination of the three dimensIonal structure of hFSH. Despite a large extracellular domain of the FSH receptor and the complexity and size of both the receptor and the hFSH molecule, only a handful of hFSH amino acids are re...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2014

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dku102